Rarely seen rectum tumor with bad prognosis: A case of large cell neuroendocrine carcinoma

Rojbin Karakoyun, Mani Habibi, Seyda Gunduz, Dinc Suren, Nurullah Bülbüller


Large cell neuoendocrine carcinoma forms an extremely aggressive and poor prognostic subset of neuroendocrine tumors with a tendency to early metastasis. However palliative chemotherapy in patients with metastatic disease may provide longer progression-free survival but the important issue is to detect and surgically treat the disease at an early stage. In this article, we  present a case of  large cell neuroendocrine carcinoma of the rectum which was admitted to our hospital with a complaint of rectal bleeding for about a month and multiple dsitant metastases at the time of diagnosis. The patient received palliative chemotherapy with cisplatin plus etoposide and zoledronic acid and an overall 6 month survival time was achieved. Generalizing the screening programs for colorectal cancers and facilitating access to colonoscopy are essential for early diagnosis and therapy of rectal neuroendocrine tumors.


Rectal Neoplasms; Carcinoma, neuroendocrine; Carcinoma, large Cell

Full Text:



Pascarella M, McCloskey D, Jenab-Wolcott J, Vala M, Rovito M, McHugh J. "Large cell neuroendocrine carcinoma of the colon: A rare and aggressive tumor." J Gastrointest Oncol 2: 250-253, 2011.

Bosman F T, Camerio F, Hruban R, et al. WHO classification of tumors of the digestive system. Lyon, France: IARC Press; 2010.

Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S: The pathologic classification of neuroendocrine tumors: A review of nomenclature, grading, and staging systems. Pancreas 39:707-712, 2010.

Simon SR, Fox K. Neuroendocrine carcinoma of the colon: Correct diagnosis is important. J Clin Gastroenterol 17:304-307, 1993.

Merg A, Wirtzfeld D, Wang J, Cheney R, Dunn KB, Rajput A. Viability of endoscopic and excisional treatment of early rectal carcinoids. J Gastrointest Surg 2007; 11: 893-897, 2007.

Mani S, Modlin IM, Ballantyne GH, Ahlman H, West AB. Carcinoids of the rectum. J Am Coll Surg 179: 179: 231-248, 1994.

Vilallonga R, Espin Basany E, Lopez Cano M, Landolfi S, Armengol Carrasco M. Neuroendocrine carcinomas of the colon and rectum: a unit's experience over six years. Rev Esp Enferm Dig 100:11–16, 2008.

Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, et al. Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum. 47:163-169, 2004.

Kim, H G, Lee JI, Jeong S, Lee JW, Kwon KS, Kim, H et al. A case of large cell neuroendocrine carcinoma of the colon. Korean J Gastroenterol 54: 46-49, 2009.

Park JS, Kim L, Kim CH, Bang BW, Lee DH, Jeong S, et al. Synchronous large-cell neuroendocrine carcinoma and adenocarcinoma of the colon. Gut Liver 4:122–125, 2010.

Moertel CG, Kvols LK, O'Connell MJ, Rubin J. Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer 68:227, 1991.


  • There are currently no refbacks.