Hemodynamic changes in exodontia patients using 4% articaine with 1: 100,000 epinephrine and 2% lidocaine with 1:200,000 epinephrine

Renuka Makani, Kumar Nilesh


This study was conducted to evaluate and compare the hemodynamic changes associated with intraoral injection of 4% articaine with 1: 100,000 epinephrine and 2% lidocaine with 1:200,000 epinephrine in patients undergoing dental extraction.A prospective observational study was carried out in patients undergoing tooth extraction. Local anesthesia was administered using 4% articaine with 1:100,000 epinephrine to one group (A), while other group (B) received 2% lidocaine with 1:200,000 epinephrine. The parameters that were monitored at four different points of time (in waiting room, immediately after local anesthesia injection, during tooth extraction, and 15 minutes after tooth extraction) included systolic and diastolic blood pressures, pulse rate and oxygen saturation. No statistically significant differences were observed in systolic blood pressure, diastolic blood pressure and pulse rate at any evaluation time between both groups. However, measurement of oxygen saturation showed statistically significant differences at the time of local anesthesia administration and 15 minutes after tooth extraction, with group B showing higher values (P < 0.05). Administration of 2% lidocaine with 1:200,000 epinephrine and 4% articaine with 1:100000 epinephrine was safe during tooth extraction procedure with no statistically difference in hemodynamic status between the two groups. Only oxygen saturation showed statistically significant difference at the time of local anesthesia administration and 15 minutes after tooth extraction in group B.


Exodontia, vital signs, local anesthesia, Articaine, Lidocaine

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