Survival and clinicopathologic characteristics of meningioma

Mehrdad Roozbeh, Shokouh Taghipour zahir, Mahrooz Roozbeh, Farzan SafiDahaj

Abstract


With the prevalence of one-third of intracranial brain tumors, meningioma prognosis is affected by the size, location, ability to access the tumor through surgery, and the degree of histological malignancy. We intended to investigate patients' prognosis and clinical features with central nervous system meningioma.Records of all patients with central nervous system and spinal cord meningiomas between 2006-2016 in Yazd Shahid Sadoughi, Shahid Rahnemoun, Mortaz, Goodarz, and Mojibian hospitals were studied. Using SPSS version 17, survival, age, type of treatment, grade, size, and tumor location were investigated in this retrospective cross-sectional study. Of the 175 patients (66 (37.7%) male, 109 (62.3%) female) with an average survival time of 78.5 months, tumors recurred in 12 (10.7%) patients. Among them, 63 (47%) were between 18-54, and 72 (53%) were between 55-87 years. Syncytial was the most common histological subtype, and a significant relationship between age and tumor subtype was found (p-value = 0.03). Primary symptoms of headache and nausea/vomiting were in most of them (51, 57%). The most and the most minor expected location was the brain lobes (14 cases) and the spinal cord (2 patients). There was no significant relationship between meningioma subtype-symptoms, survival-gender/ tumor subtype, recurrence-gender/ age, or tumor subtype. Also, a significant relationship between age and survival was found (p-value = 0.05).  An increase in the prevalence of meningioma in recent years has been due to improvements in imaging techniques and the population's aging. Overall, there was a significant relationship between age and meningioma prevalence.


Keywords


Meningioma, brain tumor, survival, recurrence

Full Text:

PDF

References


Alruwaili AA, De Jesus O. Meningioma. [Updated 2021 Sep 15]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www. ncbi.nlm.nih.gov/books/NBK560538/.

Kamenova M, Guzman R, Soleman J. Demogra-phics and outcome of histologically confirmed intracranial meningiomas. Clin Transl Neurosci 3:2514183X19894945, 2019.

Huntoon K, Toland AMS, Dahiya S. Meningioma: A Review of Clinicopathological and Molecular Aspects. Front Oncol 10:579599, 2020.

Riemenschneider MJ, Perry A, Reifenberger G. Histological classification and molecular genetics of meningiomas. Lancet Neurol 2006;5(12):1045–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 17110285.

Aster JC, Abbas AK. Robbins Basic Pathology. Philadelphia, PA: Elsevier Saunders; 2013.

Wanis HA, Møller H, Ashkan K, et al. The incidence of major subtypes of primary brain tumors in adults in England 1995-2017. Neuro Oncol 23:1371-1382, 2021.

Ostrom QT, Francis SS, Barnholtz-Sloan JS. Epidemiology of Brain and Other CNS Tumors. Curr Neurol Neurosci Rep 21:68, 2021.

Miller KD, Ostrom QT, Kruchko C, et al. Brain and other central nervous system tumor statistics. CA Cancer J Clin 71:381-406, 2021.

Garzon-Muvdi T, Yang W, Lim M, et al. Atypical and anaplastic meningioma: outcomes in a population-based study. J Neurooncol 133:321-330, 2017.

Fonkem E, Dandashi JA, Stroberg E, et al. A retrospective analysis of meningioma in Central Texas. J Epidemiol Glob Health 6:87-93, 2016.

Chebil C, Boumediene F, Cicero CE, et al. Epidemiology of primary brain tumors in the province of catania during the 2003-2016 period. Neuroepidemiology 55:473-483, 2021.

Barresi V, Caffo M, Tuccari G. Classification of human meningiomas: lights, shadows, and future perspectives. J Neurosci Res 94:1604-1612, 2016.

Mehrazin M, Rahmat H, Yavari P. Epidemiology of primary intracranial tumors in Iran, 1978-2003. Asian Pac J Cancer Prev 7:283, 2006.

Bitaraf MA, Azar M, Miri SM, et al. Radiosurgery for skull base meningiomas: a study on 230 cases in Iranian Gamma Knife Center. Tehran Univ Med J 68:162-167, 2010. (In Persian).

Faraji M, Birjandi A. Pediatric Meningioma. Ofogh-e-Danesh 2004;10(1):14-17, 2004. (In Persian).

Samadi N, Ahmadi SA. Meningioma: a clinicopathological evaluation. Malays J Med Sci 14:46-52, 2007.

Shiravi Khozani M, Moradi A, Solat Yekani S F, et al. Pathologic study of Ki-67 and p53 protein expression in patients with meningioma referred to Shohadaye- Tajrish hospital. Res in Med 37:102-106, 2013. (In Persian).

Taghipour M, Razmkon A, Bakhtazad A. High prevalence of intracranial meningioma in Jewish population in Shiraz, Southern Iran. Neurosurg Q 20:68-70, 2010.

Zakarian B, Tonkaboni JS. Meningioma in a dog in Iran: a case report, together with a review of the literature and special reference to the aetiology. J Small Anim Pract 12:37-43, 1971.

Mashayekhi F, Saberi A, Mashayekhi S. Serum TIMP1 and TIMP2 concentration in patients with different grades of meningioma. Clin Neurol Neurosurg 170:84-87, 2018.

Da Broi M, Borrelli P, Meling TR. Predictors of survival in atypical meningiomas. Cancers (Basel) 13:1970, 2021.

Ogasawara C, Philbrick BD, Adamson DC. Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions. Biomedicines 2021;9(3):319.

Farokhi MR, Ansari Z. Recurrence Of Intracranial Meningioma And Its Contributive Factors; A 20- Year Study. Tehran Univ Med J 65:91-96, 2007.

Fonkem E, Dandashi JA, Stroberg E, et al. A retrospective analysis of meningioma in Central Texas. J Epidemiol Glob Health 6:87-93, 2016.

Zahir ST, Vakili M, Navabii H. Clinicopathological Findings and Five-Year Survival Rates for Patients with Central Nervous System Tumors in Yazd, Iran 15:10319-1023, 2014.

Komori T. The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision. Neurol Med Chir (Tokyo) 57:301-311, 2017.

Perry A, Stafford SL, Scheithauer BW, et al. Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol 21:1455-1465, 1997.

Bhat AR, Wani MA, Kirmani AR, Ramzan AU. Histological-subtypes and anatomical location correlated in meningeal brain tumors (meningiomas). J Neurosci Rural Pract 5:244-249, 2014.

Jordan JT, Plotkin SR. Benign Intracranial Tumors. Neurol Clin 36:501-516, 2018.

Kuratsu J, Ushio Y. Epidemiological study of primary intracranial tumours in elderly people. J Neurol Neurosurg Psychiatry 63:116-118, 1997.

Kshettry VR, Hsieh JK, Ostrom QT, et al. Descriptive epidemiology of spinal meningiomas in the United States. Spine (Phila Pa 1976) 40:E886-889, 2015.

Zouaoui S, Darlix A, Rigau V, et al. Épidémiologie descriptive de 13 038 cas de méningiomes opérés en France entre 2006 et 2010. Neurochirurgie 64:15-21, 2018.

Park BJ, Kim HK, Sade B, et al. Epidemiology. In: Lee JH, editor. Meningiomas: Diagnosis, Treatment, and Outcome. London: Springer-Verlag; p 11. 2009.

Kallio M, Sankila R, Hakulinen T, et al. Factors affecting operative and excess long-term mortality in 935 patients with intracranial meningioma. Neurosurgery 31:2-12, 1992.

Pettersson-Segerlind J, Orrego A, Lönn S, et al. Long-term 25-year follow-up of surgically treated parasagittal meningiomas. World Neurosurg 76:564-571, 2011.

Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803-820, 2016.

Simpson D. The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22-39, 1957.

Rogers L, Barani I, Chamberlain M, et al. Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg 122:4-23, 2015.

McCarthy BJ, Davis FG, Freels S, et al. Factors associated with survival in patients with meningioma. J Neurosurg 88:831-839, 1998.

Das A, Tang WY, Smith DR. Meningiomas in Singapore: Demographic and biological characteristics. J Neurooncol 47:153-160, 2000.

Therapy GR, City SL. Role of radiation therapy in treating intracranial meningiomas. Neurosurg Focus 23:E4, 2007.

Ikawa F, Kinoshita Y, Takeda M, et al. Review of current evidence regarding surgery in elderly patients with meningioma. Neurol Med Chir (Tokyo) 57:521-533, 2017.

Poon MT-C, Fung LH-K, Pu JK-S, et al. Outcome of elderly patients undergoing intracranial meningioma resection – A systematic review and meta-analysis. Br J Neurosurg 28:303-309, 2014.

Rochat P, Johannesen HH, Gjerris F. Long-term follow up of children with meningiomas in Denmark: 1935 to 1984. J Neurosurg 100(2 Suppl Pediatrics):179-182, 2004.


Refbacks

  • There are currently no refbacks.


 

Best Quality Medical Supplies is a registered company in Untied States specializing in sales of medical equipment and supplies. We are a distributor for hospitals, doctor offices, medical clinics, nursing schools, and nursing homes within the United States. We also provide services for overseas clients. Click here for details and orders .




The most affordable web hosting service. Click here for details and orders.