Rarely seen rectum tumor with bad prognosis: A case of large cell neuroendocrine carcinoma

Rojbin Karakoyun, Mani Habibi, Seyda Gunduz, Dinc Suren, Nurullah Bülbüller

Abstract


Large cell neuoendocrine carcinoma forms an extremely aggressive and poor prognostic subset of neuroendocrine tumors with a tendency to early metastasis. However palliative chemotherapy in patients with metastatic disease may provide longer progression-free survival but the important issue is to detect and surgically treat the disease at an early stage. In this article, we  present a case of  large cell neuroendocrine carcinoma of the rectum which was admitted to our hospital with a complaint of rectal bleeding for about a month and multiple dsitant metastases at the time of diagnosis. The patient received palliative chemotherapy with cisplatin plus etoposide and zoledronic acid and an overall 6 month survival time was achieved. Generalizing the screening programs for colorectal cancers and facilitating access to colonoscopy are essential for early diagnosis and therapy of rectal neuroendocrine tumors.


Keywords


Rectal Neoplasms; Carcinoma, neuroendocrine; Carcinoma, large Cell

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References


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